Tatsuya OTA Associate Professor

ResearchMap: http://researchmap.jp/tota/
Google Scholar Citations: https://scholar.google.com/citations?user=NraZpoIAAAAJ

Molecular evolution, Evolution of biosystems

As the analyses of omics such as genomes and transcriptomes have been progressed for the increasing number of species, it becomes possible to study an organism as a whole, with recognizing each and every underlying system as product of complexed expression of genes involved. In our laboratory, with emphasizing the viewpoints of molecular evolution and population genetics, a few biosystems have been studied to solve questions such as “How have the mutations of individual genes led to phenotypical changes and become subject to natural selection?” or “How have complex systems been formed through the accumulation of mutations?”. With the aims in mind, we have conducted specific researches on the followings: (1) the evolution of reproductive systems in Polygonaceae, such as the heteromorphic self-incompatibility system in buckwheat in which one genetic locus controls dimorphic flower type as well as self-incompatibility, (2) the evolution of immune systems such as adaptive and innate immune system of fishes, and (3) adaptive evolution of notothenioid fishes, which have attained numerous unique characters upon the cooling of the Southern Ocean after the geological isolation of Antarctica.


Papers and publications

  1. I. Braasch et al., (2016)
    The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
    Nature Genetics 48, 427-437.
  2. C.T. Amemiya, J. Alföldi, et al. (2013)
    The African coelacanth genome provides insights into tetrapod evolution.
    Nature 496, 311-316.
  3. Y. Yasui, M. Mori, J. Aii, T. Abe, D. Matsumoto, S. Sato, Y. Hayashi, O. Ohnishi, and T. Ota (2012)
    S-LOCUS EARLY FLOWERING 3 Is Exclusively Present in the Genomes of Short-Styled Buckwheat Plants that Exhibit Heteromorphic Self-Incompatibility.
    PLoS ONE 7, e31264.
  4. T. Ota, J. P. Rast, G. W. Litman, and C. T. Amemiya (2003)
    Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox.
    Proceedings of the National Academy of Sciences USA 100, 2501-2506.
  5. T. Ota, and M. Nei (1994)
    Divergent evolution and evolution by the birth-and-death process in the immunoglobulin V(H) gene family.
    Molecualr Biology and Evolution 11, 469-482.