Hideki INNAN Professor

Lab web site: https://sites.google.com/view/innanlab
Google Scholar Citations: https://scholar.google.com/citations?user=6wnEbLsAAAAJ

Population Genetics, Evolutionary Genomics

Our research interest is the analysis of the process of evolution at the DNA level. For example, the DNA sequences of two humans average one base difference per approximately 1000 bases. This is equivalent to 1/10 to 1/15 of the base differences between humans and chimpanzees. The type of evolutionary model that can explain such differences needs to be discovered. In particular, our aim is to clarify when, where (in genomes), and how Darwinian natural selection has worked and how it has contributed to the formation of diverse species. Research methods include theoretical approaches, data analysis, and simple experiments. I myself have been long engaged in theoretical studies, but our laboratory also conducts data analysis and experiments. Our subject organisms range from bacteria and enzymes to plants and animals. We place primary importance on the education of students to foster outstanding young researchers in this discipline. Each member of the laboratory is expected to take the initiative to independently study a topic of his/her choice. No restrictions are placed on research topics (and subject organisms), as long as the topics are related to DNA evolution. Our laboratory works on a wide range of research topics, e.g. adaptive evolution, gene duplication, horizontal gene transfer, sexual evolution, and theoretical analysis of population genetics.


Papers and publications

  1. Fawcett, J. A., and H. Innan, 2013. The role of gene conversion in preservation of rearrangement hotspots in the human genome. Trends Genet. 29: 561-568.
  2. Innan, H., and F. Kondrashov, 2010. The evolution of gene duplications: classifying and distinguishing between models. Nat. Rev. Genet. 11: 97-108.
  3. Osada, N., and H. Innan, 2008. Duplication and gene conversion in the Drosophila melanogaster genome. PLoS Genet. 4: e1000305.
  4. Gao, L. Z., and H. Innan, 2004. Very low gene duplication rate in the yeast genome. Science 306: 1367-1370.
  5. Innan, H., 2003. A two-locus gene conversion model with selection and its application to the human RHCE and RHD genes. PNAS. 100: 8793-8798.